| First Author | Kennell JA | Year | 2001 |
| Journal | Cytogenet Cell Genet | Volume | 92 |
| Issue | 3-4 | Pages | 337-41 |
| PubMed ID | 11435709 | Mgi Jnum | J:70475 |
| Mgi Id | MGI:2137439 | Doi | 10.1159/000056924 |
| Citation | Kennell JA, et al. (2001) cDNA cloning, chromosomal localization and evolutionary analysis of mouse vacuolar ATPase subunit D, Atp6m. Cytogenet Cell Genet 92(3-4):337-41 |
| abstractText | The multi-subunit vacuolar ATPase pump uses ATP hydrolysis to move protons into membrane bound compartments. The pump is involved in a variety of cellular functions, including regulation of cytosolic pH, vesicular transport, endocytosis, secretion, and apoptosis. Here, we describe the cDNA cloning and chromosomal mapping of subunit D of murine V-ATPase. The mouse gene, designated Atp6m, maps to Chromosome 12, in a region of high homology with human chromosome 14q24. Evolutionary analysis of subunit D orthologs in a variety of other species reveals that this is a highly conserved protein that has been under remarkably strong negative selection during evolution, most likely reflecting its critical role in multiple cellular processes. Copyright 2001 S. Karger AG, Basel. |
