First Author | Furukawa K | Year | 1999 |
Journal | Biochim Biophys Acta | Volume | 1473 |
Issue | 1 | Pages | 54-66 |
PubMed ID | 10580129 | Mgi Jnum | J:59034 |
Mgi Id | MGI:1350803 | Doi | 10.1016/s0304-4165(99)00169-5 |
Citation | Furukawa K, et al. (1999) Beta-1,4-galactosylation of N-glycans is a complex process. Biochim Biophys Acta 1473(1):54-66 |
abstractText | Most beta-1,4-galactosyltransferase (beta-1,4-GalT)-knockout mice die after birth. Although several defects were found transiently in these animals, the primary cause of death is obscure. Not only beta-1,4-linked galactose residues on N-glycans, but also beta-1, 4-GalT activities were found in some of the tissues. Recently, five human genes which encode beta-1,4-GalTs have been cloned, and the possible presence of such novel beta-1,4-GalTs in mice is considered to bring about survival of the mutant animal beyond birth. In order to understand the semi-lethal nature of this animal, it is inevitable to clarify how individual novel beta-1,4-GalTs are involved in the biosynthesis of glycoconjugates based on their acceptor-substrate specificities. |