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Publication : Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity.

First Author  Chen L Year  2004
Journal  Brain Res Mol Brain Res Volume  129
Issue  1-2 Pages  179-84
PubMed ID  15469894 Mgi Jnum  J:115454
Mgi Id  MGI:3691733 Doi  10.1016/j.molbrainres.2004.06.018
Citation  Chen L, et al. (2004) Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity. Brain Res Mol Brain Res 129(1-2):179-84
abstractText  Prolactin (PRL) and vasoactive intestinal polypeptide (VIP) mRNA levels were elevated in the brainstem of neuronal nitric oxide synthase (nNOS) gene knockout (KO) mice compared to the levels in nNOS control mice. In addition, PRL mRNA levels increased in the hypothalamus and the brainstem of nNOS control mice after administration of 7-nitro-indazole (7-NI), a relatively selective nNOS inhibitor. The results suggest that NO inhibits PRL. No differences in the genes measured were observed in inducible NOS KO mice.
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