| First Author | Chung YH | Year | 2004 |
| Journal | Brain Res | Volume | 1021 |
| Issue | 1 | Pages | 132-9 |
| PubMed ID | 15328041 | Mgi Jnum | J:107781 |
| Mgi Id | MGI:3622014 | Doi | 10.1016/j.brainres.2004.06.043 |
| Citation | Chung YH, et al. (2004) Region-specific alterations in insulin-like growth factor-I receptor in the central nervous system of nNOS knockout mice. Brain Res 1021(1):132-9 |
| abstractText | In the present study, we investigated layer-specific changes in insulin-like growth factor-I (IGF-I) receptor localization in the cerebral cortex, hippocampus and cerebellum of neuronal nitric oxide synthase knockout (nNOS-/-) mice using immunohistochemistry. In the cerebral cortex of control mice, moderately stained cells were seen through the layers II-VI in several cortical regions. In nNOS-/- mice, there was a significant decrease in IGF-I receptor immunoreactivity in the same cortical regions. In the hippocampus of control mice, a distinct immunoreactivity pattern was observed in the CA1-3 areas and dentate gyrus. The immunoreactivity for IGF-I receptor was differentially decreased in each layer in nNOS-/- mice. In nNOS-/- cerebellum, IGF-I receptor immunoreactivity was also significantly decreased in each layer of cerebellar cortex and cerebellar nuclei. To clarify whether decreased expression of IGF-I receptor in nNOS-/- mice was specific, the expression of other receptors for IGF-I was also evaluated. Receptor tyrosine kinase type A (TrkA receptor) and TrkB receptor were differentially decreased in each layer of the hippocampus or cerebellum of nNOS-/- mice. Although further studies of functional features of IGF-I systems in the nNOS-/- mice are required, our first morphological data may provide insights into NO-induced changes in trophic support as well as basic knowledge required for the study of NO-associated neurological diseases. |
