| Primary Identifier | MGI:3052548 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene |
Tg(H2-Ea |
| Strain of Origin | NOD/ShiLt | Is Recombinase | false |
| Is Wild Type | false |
| description | Overexpression of H2-Ea in line 5 confers nearly complete resistance to IDDM. Although the presence of the transgene in both lines 5 and 12 confers protective influence from IDDM pathologies that affect pancreatic beta cells, autoimmune pathologies effecting other tissues (submandibular salivary, thyroid, kidney) are observed. Histologic examination of the pancreas reveals perivascular/periductal infiltration and peri-insulitus. |
| molecularNote | The construct contains a complete H2-Ead gene from the BALB/cByJ mouse including flanking sequence. One copy of the transgene integrated into the genome of line 12 whereas four copies are present in line 5. |
