| First Author | Nguyen HN | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 357 |
| Issue | 1 | Pages | 174-80 |
| PubMed ID | 17418105 | Mgi Jnum | J:121786 |
| Mgi Id | MGI:3711616 | Doi | 10.1016/j.bbrc.2007.03.119 |
| Citation | Nguyen HN, et al. (2007) Mutant presenilin 2 increased oxidative stress and p53 expression in neuronal cells. Biochem Biophys Res Commun 357(1):174-80 |
| abstractText | The learning and memory impairment of presenilin 2 transgenic mice was mentioned previously. In this study, exposing the presenilin 2 transfected PC12 cells to the 50 microM Abeta(25-35), 30 mM l-glutamate and 50 microM H(2)O(2) resulted in significant increase 8-oxodG and p53 levels of the cells expressing the mutant gene. The increase was also found in the mutant presenilin 2 transgenic mice brains age-dependently in comparison to that in the wild-type presenilin 2-transgenic mice and non-transgenic ones. These findings indicated that mutant presenilin 2 clearly increases oxidative stress and p53 expression, which could be implicated in promoting mutant presenilin 2-induced neurodegeneration in Alzheimer's disease, and the influence of mutant presenilin 2 in Alzheimer's disease may be brain regional and age related effects. |
