| First Author | Shih AH | Year | 2012 |
| Journal | Cancer Cell | Volume | 22 |
| Issue | 3 | Pages | 285-7 |
| PubMed ID | 22975371 | Mgi Jnum | J:192908 |
| Mgi Id | MGI:5466800 | Doi | 10.1016/j.ccr.2012.08.022 |
| Citation | Shih AH, et al. (2012) IDH1 mutations disrupt blood, brain, and barriers. Cancer Cell 22(3):285-7 |
| abstractText | The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of collagen and prolyl hydroxylases lead to altered microenvironment and defective angiogenesis. |
