| Primary Identifier | MGI:1913799 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 66549 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable nucleic acid binding activity. Predicted to be involved in cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to act upstream of or within angiogenesis and cell differentiation. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; egg cylinder; genitourinary system; primitive streak; and sensory organ. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1). PHENOTYPE: Homozygous null embryos die before E8.5. Heterozygotes exhibit defective angiogenesis in yolk sacs and embryos and partial lethality. Surviving adults show hemorrhages, increased vascular permeability, and reduced tumor growth of implanted melanoma cell lines. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
