| Primary Identifier | MGI:1926471 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 60534 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Acts upstream of or within several processes, including DNA damage response; ovarian follicle development; and spermatid development. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nucleolus. Predicted to be part of Fanconi anaemia nuclear complex and chromatin. Is expressed in gut dorsal mesentery and reproductive system. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group G; and pancreatic cancer. Orthologous to human FANCG (FA complementation group G). PHENOTYPE: Females and males homozygous for targeted null mutations exhibit hypogonadism and reduced fertility. Cytogeneic analysis showed somatic chromosome aberrations occur at a higher spontaneous rate and are easier to induce than in normal cells. Cells are also more sensitive to mitomycin C. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
