| Primary Identifier | IPR034088 | Type | Family |
| Short Name | Pla_a_1-like |
| description | This entry includes pollen allergen Pla a 1 protein from Platanus acerifolia (London plane tree) and its homologues, including pectinesterase inhibitor 12 from Arabidopsis [].The major Platanus acerifolia pollen allergen Pla a 1 belongs to a class of allergens related to proteinaceous invertase and pectin methylesterase inhibitors. Platanus acerifolia is an important cause of pollinosis; Pla a 1 has a prevalence of about 80% among plane tree pollen-allergic patients []. Recombinant Pla a 1 binds IgE in vitro, similar to its natural counterpart, rendering it suitable for specific diagnosis and structural studies [].Invertase inhibitors are structurally similar to those of pectin methylesterase (PMEIs), an enzyme that is involved in the control of pectin metabolism and is structurally unrelated to invertases []. All inhibitors share a size of about 18kDa, two strictly conserved disulfide bridges and only moderate sequence homology (about 20% sequence identity) []. |
