| Primary Identifier | IPR045797 | Type | Family |
| Short Name | EVA_Class_A |
| description | Evasins are secreted glycoproteins from ticks, that enhance host blood flow and have anti-inflammatory activity. They bind to chemokines and prevent leukocyte recruitment [, , , ]. Based on the chemokine selectivity they can be divided in two classes: Class A binds CC chemokines and includes Evasin-1 (EVA-1) and Evasin-4, being EVA-1 more selective; Class B Evasins include Evasin-3 which binds and inhibits several CXC chemokines but not CC chemokines.This family represents class A evasins, which contain eight conserved Cys residues that define four intramolecular disulfide bonds. The N- and C-terminal regions are flexible, extend from either side of the core and form a concave surface with the first β-sheet suitable for binding another EVA-1 molecule or to a chemokine. There are two Gly residues strictly conserved. Predicted glycosylation sites were identified on the exterior surface of the structure. Due to its anti-inflammatory activity, these proteins are interesting therapeutic agents [, ]. |
