| First Author | He S | Year | 2019 |
| Journal | FEBS Open Bio | Volume | 9 |
| Issue | 3 | Pages | 498-509 |
| PubMed ID | 30868058 | Mgi Jnum | J:283107 |
| Mgi Id | MGI:6359089 | Doi | 10.1002/2211-5463.12587 |
| Citation | He S, et al. (2019) Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin-knockout mice. FEBS Open Bio 9(3):498-509 |
| abstractText | High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein-coupled receptor APJ and has possible roles in energy metabolism. Apelin-null mice have been reported to exhibit impaired insulin sensitivity, which can be reversed by supplementation of exogenous apelin. Here, we examined the effects of 4 weeks' intermittent hypoxia exposure on physiological and biochemical variables in apelin knockout (KO) mice. Apelin KO mice exhibited decreased expression of substrate metabolism-associated genes/proteins, impaired glucose tolerance, and reduced exercise capacity compared to wild-type mice, and all of these effects were rescued by hypoxia. These findings suggest that hypoxia intervention may possibly be able to alleviate metabolic conditions caused by genetic defects. |
