| First Author | Lutzny G | Year | 2013 |
| Journal | Cancer Cell | Volume | 23 |
| Issue | 1 | Pages | 77-92 |
| PubMed ID | 23328482 | Mgi Jnum | J:194342 |
| Mgi Id | MGI:5473458 | Doi | 10.1016/j.ccr.2012.12.003 |
| Citation | Lutzny G, et al. (2013) Protein kinase c-beta-dependent activation of NF-kappaB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell 23(1):77-92 |
| abstractText | Tumor cell survival critically depends on heterotypic communication with benign cells in the microenvironment. Here, we describe a survival signaling pathway activated in stromal cells by contact to B cells from patients with chronic lymphocytic leukemia (CLL). The expression of protein kinase C (PKC)-betaII and the subsequent activation of NF-kappaB in bone marrow stromal cells are prerequisites to support the survival of malignant B cells. PKC-beta knockout mice are insusceptible to CLL transplantations, underscoring the in vivo significance of the PKC-betaII-NF-kappaB signaling pathway in the tumor microenvironment. Upregulated stromal PKC-betaII in biopsies from patients with CLL, acute lymphoblastic leukemia, and mantle cell lymphoma suggests that this pathway may commonly be activated in a variety of hematological malignancies. |
