| Primary Identifier | IPR026995 | Type | Family |
| Short Name | Astrotactin |
| description | Astrotactin-1 and 2 (ASTN1/2) are integral membrane perforin-like, vertebrate-specific proteins that play critical roles in neurodevelopment [, ]. They consist of an N-terminal cytosolic domain suspended between two transmembrane α-helices with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN2. ASTN1 acts as a neuronal receptor for granule neuron migration along astroglial fibres []. ASTN2 forms a complex with ASTN1, which regulates the surface expression of ASTN1. It mediates ASTN1 recycling by promoting its internalisation and transport during endocytosis []. ASTN2 is also involved in the planar cell polarity pathway in hair cells []. |
