| First Author | Chu TH | Year | 2013 |
| Journal | Cancer Lett | Volume | 337 |
| Issue | 1 | Pages | 115-24 |
| PubMed ID | 23726841 | Mgi Jnum | J:199100 |
| Mgi Id | MGI:5500846 | Doi | 10.1016/j.canlet.2013.05.032 |
| Citation | Chu TH, et al. (2013) miR-211 promotes the progression of head and neck carcinomas by targeting TGFbetaRII. Cancer Lett 337(1):115-24 |
| abstractText | miR-211 up-regulation and transforming growth factor-beta type II receptor (TGFbetaRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFbetaRII with the miR-211-TGFbetaRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211 and TGFbetaRII expression was found in metastatic HNSCC samples. After 4-nitroquinoline 1-oxide induction, more severe epithelial tumorigenesis was detected on K14-miR-211 transgenic mouse dorsal tongues. Human metastatic lesions and mouse tongue tumors showed increased nuclear c-Myc expression. A novel role for miR-211 in the regulation of TGFbetaRII and c-Myc during tumorigenesis being revealed should help to develop anti-HNSCC therapies. |
