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Protein Coding Gene : Sp1 trans-acting transcription factor 1

Primary Identifier  MGI:98372 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  20683
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and response to hydroperoxide. Acts upstream of or within several processes, including embryo development; hemopoiesis; and mRNA transcription by RNA polymerase II. Located in nucleus. Part of chromatin. Is expressed in several structures, including central nervous system; early conceptus; epithelium; eye; and genitourinary system. Orthologous to human SP1 (Sp1 transcription factor).
PHENOTYPE: Homozygous null mice display reduced embryo size and die during organogenesis with a broad range of developmental defects. Heterozygous null mice are viable but slightly growth retarded, may lack one or both eyes, and show a decreased erythroid progenitor cell number in fetal liver cultures. [provided by MGI curators]
  • synonyms:
  • MGI:3034478,
  • MGI:1915735,
  • MGI:2146073,
  • MGD-MRK-14512,
  • expressed sequence AI845540,
  • trans-acting transcription factor 1,
  • Sp1-1,
  • RIKEN cDNA 1110003E12 gene,
  • AA450830,
  • AI845540,
  • 1110003E12Rik,
  • expressed sequence AA450830,
  • Sp1

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

20 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For