| First Author | Bar R | Year | 2018 |
| Journal | Alzheimers Dement (Amst) | Volume | 10 |
| Pages | 1-11 | PubMed ID | 29159264 |
| Mgi Jnum | J:303522 | Mgi Id | MGI:6515846 |
| Doi | 10.1016/j.dadm.2017.08.003 | Citation | Bar R, et al. (2018) The effects of apolipoprotein E genotype, alpha-synuclein deficiency, and sex on brain synaptic and Alzheimer's disease-related pathology. Alzheimers Dement (Amst) 10:1-11 |
| abstractText | Introduction: Alzheimer's disease (AD) and synucleinopathies share common pathological mechanisms. Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for AD, also increases the risk for dementia in pure synucleinopathies. We presently examined the effects of alpha-synuclein deficiency (alpha-syn-/-) and sex on apoE4-driven pathologies. Methods: AD-related, synaptic, and vascular markers were analyzed in female and male alpha-syn-/- and alpha-syn+/+ apoE4, apoE3, and apoE3/E4 mice. Results: ApoE4 was hypolipidated, and this effect was unchanged by alpha-syn-/- and sex. The levels of synaptic markers were lower, and the levels of AD-related parameters were higher in female alpha-syn-/- apoE4 mice compared with the corresponding apoE3 mice. By comparison, apoE4 had small effects on the AD parameters of male and female alpha-syn+/+ apoE4 mice. Discussion: Although alpha-syn-/- does not affect the upstream lipidation impairment of apoE4, it acts as a "second hit" enhancer of the subsequent apoE4-driven pathologies. |
