| First Author | Bock T | Year | 1991 |
| Journal | APMIS | Volume | 99 |
| Issue | 11 | Pages | 989-92 |
| PubMed ID | 1958355 | Mgi Jnum | J:2720 |
| Mgi Id | MGI:51242 | Doi | 10.1111/j.1699-0463.1991.tb01289.x |
| Citation | Bock T, et al. (1991) Reduction of diabetes incidence in NOD mice by neonatal glucose treatment. APMIS 99(11):989-92 |
| abstractText | The aim of this study was to investigate whether neonatal glucose treatment influences the incidence of diabetes in NOD mice. Thirty-nine NOD mice (19 males, 20 females) were treated with 8 g glucose/kg BW/day administered by subcutaneous injections twice a day for the first six days of life. Thirty-six untreated NOD mice (20 males, 16 females) served as a control group. In the glucose-treated group, 33% became diabetic compared with 58% in the control group (X2 = 5.3, p = 0.021). Among the glucose-treated males, 16% became diabetic compared with 50% of the untreated males (X2 = 5.5, p = 0.019), whereas 50% of the glucose-treated females became diabetic compared with 69% of the untreated females (X2 = 1.1, NS). We conclude that neonatal glucose treatment can reduce the diabetes incidence in NOD mice. These results could have implications for the prevention of type 1 diabetes mellitus in humans. |
