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Protein Coding Gene : Wipf1 WAS/WASL interacting protein family, member 1
Primary Identifier  MGI:2178801 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  215280
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable SH3 domain binding activity and protein folding chaperone. Acts upstream of or within actin filament-based movement and response to other organism. Located in actin filament. Orthologous to human WIPF1 (WAS/WASL interacting protein family member 1).
PHENOTYPE: Homozygous mutants have immunological abnormalities, although lymphocyte development appears normal. Mutants show abnormal B and T cell proliferative responses, high serum immunoglobulin levels and impaired immunological synapse formation. [provided by MGI curators]
  • synonyms:
  • DNA segment, Chr 2, ERATO Doi 120, expressed,
  • Wiskott-Aldrich syndrome protein interacting protein,
  • D2Ertd120e,
  • MGI:1196354,
  • MGI:2138838,
  • AI115543,
  • Waspip,
  • expressed sequence AI115543,
  • WIP,
  • WAS/WASL interacting protein family, member 1,
  • Wipf1
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7 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

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9 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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