Primary Identifier | IPR033503 | Type | Family |
Short Name | GW182 |
description | Protein Gawky (also known as GW182) plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs) [, ]. It is a component of cytoplasmic mRNA processing bodies required for early Drosophila development []. GW182 interacts with AGO1, and this interaction is essential for silencing by miRNAs []. It recruits the CCR4-NOT deadenylase complex through the interaction with PABPC1 []. |