| First Author | Morrow MA | Year | 1999 |
| Journal | Mol Immunol | Volume | 36 |
| Issue | 8 | Pages | 491-503 |
| PubMed ID | 10475604 | Mgi Jnum | J:56906 |
| Mgi Id | MGI:1342884 | Doi | 10.1016/s0161-5890(99)00071-1 |
| Citation | Morrow MA, et al. (1999) Overexpression of the Helix-Loop-Helix protein Id2 blocks T cell development at multiple stages. Mol Immunol 36(8):491-503 |
| abstractText | The Id proteins are inhibitors of basic-Helix-Loop-Helix transcription factor function that have been implicated in the control of cell differentiation and proliferation. To study the role of Id proteins in the control of T cell development, we generated transgenic mice that overexpress the Id2 protein in thymocytes. We detect a significant expansion of the early CD4(-)CD8(+)TCR(-) thymocyte stage and a depletion of the thymocytes of the subsequent developmental stages. These data indicate that the overexpression of Id2 leads to a stage-specific developmental block early in thymopoiesis. In addition, progeny mice from five of the six Id2 transgenic founder lines succumb to aggressive T cell hyperproliferation that resembles lymphoma. Thus, overexpression of the Id2 protein has profound effects on T cell development and oncogenesis, consistent with the hypothesis that the bHLH proteins play critical roles in these processes. |
