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Publication : Molecular cloning and characterization of mouse stanniocalcin cDNA.

First Author  Chang AC Year  1996
Journal  Mol Cell Endocrinol Volume  124
Issue  1-2 Pages  185-7
PubMed ID  9027337 Mgi Jnum  J:37688
Mgi Id  MGI:85080 Doi  10.1016/s0303-7207(96)03929-9
Citation  Chang AC, et al. (1996) Molecular cloning and characterization of mouse stanniocalcin cDNA. Mol Cell Endocrinol 124(1-2):185-7
abstractText  In bony fish, stanniocalcin is a glycoprotein hormone thought to be an important regulator of calcium uptake from the aquatic environment. Although stanniocalcin was previously thought to be unique to fish, recent evidence has indicated the existence of a human homologue. To facilitate studies of the function of stanniocalcin in mammals, we have now isolated the mouse stanniocalcin cDNA. This cDNA encodes a predicted protein of the same length as its human counterpart and with a high level of similarity (238/247) amino acids are identical, and five represent conservative changes). As in human, the mRNA is expressed in many mouse tissues, suggesting that mammalian stanniocalcin has a paracrine rather than endocrine role.
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