| First Author | Cruz-Munoz ME | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 3 | Pages | 297-305 |
| PubMed ID | 19151721 | Mgi Jnum | J:145969 |
| Mgi Id | MGI:3836377 | Doi | 10.1038/ni.1693 |
| Citation | Cruz-Munoz ME, et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol 10(3):297-305 |
| abstractText | CRACC is a self-associating member of the signaling lymphocytic activation molecule family that is expressed on cells of the immune system, including natural killer cells and activated T cells. Here we examine the function and mechanism of action of CRACC using several complementary approaches, including the generation of a CRACC-deficient mouse. Our results demonstrate that CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins. |
