| Primary Identifier | MGI:2449070 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Col2a1)1Vuo |
| Strain of Origin | (C57BL/6 x DBA/2)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Founder Del1 carries 6 integrated copies of the transgene. Founder Del1 and its heterozygous F1 offspring all exhibit smaller size compared to wild-type, but when bred to homozygosity the offspring exhibit severe short-limbed dwarfism. |
| molecularNote | A mouse Col2a1 gene deleted for a 150 bp region containing exon 7 and intron 7 was used for the transgene. 3 kb of mouse Col2a1 promoter sequences were used to drive transgene expression in chondrocytes. The transgene is expressed predominantly in the cartilage and eye as determined by RT-PCR analysis of transgenic tissues. |
