| Primary Identifier | IPR039915 | Type | Family |
| Short Name | TACC |
| description | The TACC protein family localises to the centrosome (the spindle pole body in fungi) and mitotic spindle, and plays a crucial role in bipolar spindle assembly [, ]. Furthermore, Alp7/TACC recruits kinesin-8-PP1 to the kinetochore to regulate timely mitotic progression and chromosome movement during anaphase A [].There is only one TACC protein in the nematode Caenorhabditis elegans (TAC-1), in Drosophila melanogaster (D-TACC), in Xenopus laevis (Maskin), and in fission yeast (Alp7 also known as Mia1p); by contrast, mammals have three TACC proteins (TACC1, TACC2 and TACC3) []. |
