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Protein Coding Gene : Lyn LYN proto-oncogene, Src family tyrosine kinase

Primary Identifier  MGI:96892 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  17096
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables SH3 domain binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphatidylinositol 3-kinase activator activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of leukocyte proliferation; and regulation of signal transduction. Acts upstream of or within several processes, including B cell receptor signaling pathway; neuroinflammatory response; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including membrane raft; nucleus; and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Used to study systemic lupus erythematosus. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase).
PHENOTYPE: Homozygotes for targeted null mutations exhibit splenomegaly, reduced numbers of peripheral B cells, impaired immune responses, IgM hyperglobulinemia, autoimmunity with glomerulonephritis, and monocyte/macrophage tumors. [provided by MGI curators]
  • synonyms:
  • hemopoietic cell kinase 2,
  • expressed sequence AA407514,
  • LYN proto-oncogene, Src family tyrosine kinase,
  • AA407514,
  • Yamaguchi sarcoma viral (v-yes-1) oncogene homolog,
  • Hck-2,
  • MGD-MRK-10668,
  • MGD-MRK-12071,
  • MGI:2140121,
  • Lyn

Features --> Cross References

Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

50 Pathways

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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