| First Author | Courtois G | Year | 2006 |
| Journal | Cell Death Differ | Volume | 13 |
| Issue | 5 | Pages | 843-51 |
| PubMed ID | 16397577 | Mgi Jnum | J:126297 |
| Mgi Id | MGI:3760960 | Doi | 10.1038/sj.cdd.4401841 |
| Citation | Courtois G, et al. (2006) NF-kappaB-related genetic diseases. Cell Death Differ 13(5):843-51 |
| abstractText | The recent identification of genetic diseases (incontinentia pigmenti, anhidrotic ectodermal dysplasia with immunodeficiency and cylindromatosis) resulting from mutations affecting components of the nuclear factor-kappaB (NF-kappaB) signaling pathway provides a unique opportunity to understand the function of NF-kappaB in vivo. Besides confirming the importance of NF-kappaB in innate and acquired immunity or bone mass control, analysis of these diseases has uncovered new critical roles played by this transcription factor in the development and homeostasis of the epidermis and the proper function of lymphatic vessels. In addition, the identified mutations will help understanding at the molecular level how NF-kappaB is activated in response to cell stimulation. |
