| First Author | Stokes RW | Year | 1990 |
| Journal | Clin Exp Immunol | Volume | 81 |
| Issue | 1 | Pages | 109-15 |
| PubMed ID | 2116245 | Mgi Jnum | J:23458 |
| Mgi Id | MGI:71142 | Doi | 10.1111/j.1365-2249.1990.tb05299.x |
| Citation | Stokes RW, et al. (1990) Passive transfer of immunity of Mycobacterium avium in susceptible and resistant strains of mice. Clin Exp Immunol 81(1):109-15 |
| abstractText | Naturally susceptible mice (C57BL/6) infected with M. avium (strain Weybridge) developed a population of splenic T cells which, on transfer to syngeneic recipient mice, conferred significant protection against a subsequent challenge inoculum of M. avium. Similar T cells from naturally resistant mice (A/J) did not protect syngeneic recipient mice. Growth of M. avium in donor mice only occurred in the C57BL/6 strain. Replication of M. avium in donor mice was necessary for the development of protective T cells. High numbers of killed mycobacterium did not induce immune T cells. In addition, A/J mice inoculated with increasing numbers of viable M. avium (which still did not replicate) failed to develop protective T lymphocytes. Further studies indicated that no protective T cells were present in the M. avium-infected A/J mouse, although evidence for non-specific immunity in these mice was obtained. In addition, BCG (which grows progressively in A/J mice) stimulated a population of splenic T cells which protected recipient mice from subsequent infection with M. tuberculosis. |
