| First Author | Jiao Y | Year | 2014 |
| Journal | Diabetes | Volume | 63 |
| Issue | 4 | Pages | 1283-8 |
| PubMed ID | 24353178 | Mgi Jnum | J:217254 |
| Mgi Id | MGI:5613447 | Doi | 10.2337/db13-1435 |
| Citation | Jiao Y, et al. (2014) Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting. Diabetes 63(4):1283-8 |
| abstractText | The recent discovery of betatrophin, a protein secreted by the liver and white adipose tissue in conditions of insulin resistance and shown to dramatically stimulate replication of mouse insulin-producing beta-cells, has raised high hopes for the rapid development of a novel therapeutic approach for the treatment of diabetes. At present, however, the effects of betatrophin on human beta-cells are not known. Here we use administration of the insulin receptor antagonist S961, shown to increase betatrophin gene expression and stimulate beta-cell replication in mice, to test its effect on human beta-cells. Although mouse beta-cells, in their normal location in the pancreas or when transplanted under the kidney capsule, respond with a dramatic increase in beta-cell DNA replication, human beta-cells are completely unresponsive. These results put into question whether betatrophin can be developed as a therapeutic approach for treating human diabetes. |
