| First Author | Berge G | Year | 2004 |
| Journal | Br J Cancer | Volume | 91 |
| Issue | 7 | Pages | 1380-3 |
| PubMed ID | 15316568 | Mgi Jnum | J:92919 |
| Mgi Id | MGI:3054739 | Doi | 10.1038/sj.bjc.6602125 |
| Citation | Berge G, et al. (2004) Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene. Br J Cancer 91(7):1380-3 |
| abstractText | Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzo[a]pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs.British Journal of Cancer (2004) 91, 1380-1383. doi:10.1038/sj.bjc.6602125 www.bjcancer.com Published online 17 August 2004 |
