| Primary Identifier | IPR028456 | Type | Family |
| Short Name | ABI1 |
| description | Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for cytoskeletal reorganization []. Abi1 and Abi2 play an important role in actin cytoskeleton dynamics through participation in several multiprotein complexes. They participate in the formation of the Abi/WAVE complex, which regulates Arp2/3-mediated actin filament nucleation and actin network assembly [, , ].Abi1 promotes tyrosine phosphorylation of mammalian enabled (Mena) by c-Abl kinase []. It is essential for WAVE2 complex integrity and embryonic survival in mice []. Abi1 and the p85 regulatory subunit of PI-3 kinase may be the link between actin cytoskeleton remodelling and growth receptor signalling []. |
