| First Author | Saunders A | Year | 2010 |
| Journal | Blood | Volume | 115 |
| Issue | 16 | Pages | 3249-57 |
| PubMed ID | 20194894 | Mgi Jnum | J:160782 |
| Mgi Id | MGI:4455099 | Doi | 10.1182/blood-2009-08-237586 |
| Citation | Saunders A, et al. (2010) Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes. Blood 115(16):3249-57 |
| abstractText | The guanosine triphosphatases (GTPases) of the immunity-associated protein (GIMAP) family of putative GTPases has been implicated in the regulation of T-lymphocyte development and survival. A mouse conditional knockout allele was generated for the immune GTPase gene GIMAP1. Homozygous loss of this allele under the influence of the lymphoid-expressed hCD2-iCre recombinase transgene led to severe (> 85%) deficiency of mature T lymphocytes and, unexpectedly, of mature B lymphocytes. By contrast there was little effect of GIMAP1 deletion on immature lymphocytes in either B or T lineages, although in vitro studies showed a shortening of the survival time of both immature and mature CD4(+) single-positive thymocytes. These findings show a vital requirement for GIMAP1 in mature lymphocyte development/survival and draw attention to the nonredundant roles of members of the GIMAP GTPase family in these processes. |
