| First Author | González-Billault C | Year | 2005 |
| Journal | Cereb Cortex | Volume | 15 |
| Issue | 8 | Pages | 1134-45 |
| PubMed ID | 15590913 | Mgi Jnum | J:144158 |
| Mgi Id | MGI:3830181 | Doi | 10.1093/cercor/bhh213 |
| Citation | Gonzalez-Billault C, et al. (2005) A role of MAP1B in Reelin-dependent neuronal migration. Cereb Cortex 15(8):1134-45 |
| abstractText | The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration. |
