| First Author | Chadi S | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 390 |
| Issue | 3 | Pages | 1040-3 |
| PubMed ID | 19857464 | Mgi Jnum | J:155605 |
| Mgi Id | MGI:4414873 | Doi | 10.1016/j.bbrc.2009.10.104 |
| Citation | Chadi S, et al. (2009) R-spondin1 is required for normal epithelial morphogenesis during mammary gland development. Biochem Biophys Res Commun 390(3):1040-3 |
| abstractText | The R-spondin (Rspo) proteins constitute a novel class of ligands that induce Wnt signalling. Rspo1 knockout XX mice were previously shown to be sex-reversed, but some remain sub-fertile. These last were unable to feed their pups for some unknown reason. Using these mice and transplanted mammary tissues from Rspo1(-/-) virgin mice in nude mice, we report that the lack of Rspo1 expression results in the absence of duct side-branching development and subsequent alveolar formation, explaining the above mentioned phenotype. Our data demonstrate that local epithelial Rspo1 signalling is required for normal development of the mammary gland. |
