| Primary Identifier | IPR017380 | Type | Family |
| Short Name | Hist_AcTrfase_B-typ_cat-su |
| description | This entry represents the catalytic subunit of histone acetyltransferase type B () (also known as HAT1), which is the catalytic component of the histone acetylase B (HAT-B) complex [, , ]. The HAT-B complex is composed of at least HAT1 and HAT2. In the cytoplasm, this complex binds to the histone H4 tail. In the nucleus, the HAT-B complex has an additional component, the histone H3/H4 chaperone HIF1.This enzyme acetylates soluble but not nucleosomal H4 at Lys-12, which is required for telomeric silencing. HAT1 has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. It is involved in DNA double-strand break repair []. |
