| First Author | Li J | Year | 2017 |
| Journal | FEBS Lett | Volume | 591 |
| Issue | 7 | Pages | 1018-1028 |
| PubMed ID | 28236654 | Mgi Jnum | J:241643 |
| Mgi Id | MGI:5903328 | Doi | 10.1002/1873-3468.12610 |
| Citation | Li J, et al. (2017) Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice. FEBS Lett 591(7):1018-1028 |
| abstractText | Sortilin 1 (Sort1) is a trafficking receptor that has been implicated in the regulation of plasma cholesterol in humans and mice. Here, we use metabolomics and hyperinsulinemic-euglycemic clamp approaches to obtain further understanding of the in vivo effects of Sort1 deletion on diet-induced obesity as well as on adipose lipid and glucose metabolism. Results show that Sort1 knockout (KO) does not affect Western diet-induced obesity nor adipose fatty acid and ceramide concentrations. Under the basal fasting state, chow-fed Sort1 KO mice have decreased adipose glycolytic metabolites, but Sort1 deletion does not affect insulin-stimulated tissue glucose uptake during the insulin clamp. These results suggest that Sort1 loss-of-function in vivo does not affect obesity development, but differentially modulates adipose glucose metabolism under fasting and insulin-stimulated states. |
