| First Author | Do JS | Year | 2009 |
| Journal | Blood | Volume | 113 |
| Issue | 25 | Pages | 6361-71 |
| PubMed ID | 19380870 | Mgi Jnum | J:150154 |
| Mgi Id | MGI:3849799 | Doi | 10.1182/blood-2008-12-192997 |
| Citation | Do JS, et al. (2009) IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo. Blood 113(25):6361-71 |
| abstractText | Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that gammadelta T cells limit CD8 T-cell expansion but not the initial proliferation after transfer into lymphopenic recipients. Interleukin-15 (IL-15) produced by and trans-presented on the membrane of the CD11c(+) dendritic cells (DCs) is the key factor that mediates homeostatic competition between CD8 and gammadelta T cells, revealing previously unrecognized IL-15-dependent homeostatic mechanisms between different T-cell subsets in vivo. |
