| First Author | Bergtold A | Year | 2005 |
| Journal | Immunity | Volume | 23 |
| Issue | 5 | Pages | 503-14 |
| PubMed ID | 16286018 | Mgi Jnum | J:113283 |
| Mgi Id | MGI:3665351 | Doi | 10.1016/j.immuni.2005.09.013 |
| Citation | Bergtold A, et al. (2005) Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14 |
| abstractText | Dendritic cells process internalized antigens to present degradative products on MHC for TCR recognition. Because antigen-exposed DCs also induce humoral immunity, DCs must also retain antigen in its native state for the engagement of BCR on B cells. Here, we demonstrate that antigen endocytosed by the inhibitory Fc receptor, FcgammaRIIB, accesses a non-degradative intracellular vesicular compartment that recycles to the cell surface, enabling interaction of native antigen with BCR on B cells. Immunization with IgG-opsonized, T independent antigens leads to enhanced humoral responses in a FcgammaRIIB and complement dependent manner. IC-loaded DCs trafficking to the splenic marginal zone can prime a T independent response in an FcgammaRIIB-dependent manner. Thus dendritic cells are equipped with both non-degradative and degradative antigen uptake pathways to facilitate antigen presentation to both B and T cells. |
