| Primary Identifier | IPR030343 | Type | Family |
| Short Name | SLC12A8 |
| description | The electroneutral cation-chloride-coupled cotransporter gene family (SLC12) consists of nine members and encompasses two major branches. One brach includes three genes (SLC12A1-SLC12A3) encoding two bumetanide-sensitive Na+-K+-2Cl- cotransporters (NKC) and a thiazide-sensitive Na+:Cl- cotransporter (NC). The second branch includes four genes (SLC12A4-7) encoding electroneutral K+-Cl- cotransporters (KCC). The transported substrates of the remaining two SLC12 family members, SLC12A8 and SLC12A9, are unknown [].Solute carrier family 12 member 8 (SLC12A8) is also known as CCC9 (cation-chloride cotransporter 9). A splice variant of CCC9 (CCC9a) has been shown to promote polyamine-amino acid transport []. |
