| Primary Identifier | MGI:97587 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 18715 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and protein stabilization. Acts upstream of or within apoptotic mitochondrial changes; negative regulation of apoptotic process; and positive regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in several structures, including exocrine gland; genitourinary system; hemolymphoid system gland; nervous system; and nose. Orthologous to human PIM2 (Pim-2 proto-oncogene, serine/threonine kinase). PHENOTYPE: Homozygous null mice display reduced T cell proliferation in response to suboptimal alphaCD3 activation. Mice homozygous for a null allele exhibit reduced LPS-stimulated IL6 production from splenotcytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
