| First Author | Saint-Ruf C | Year | 1994 |
| Journal | Science | Volume | 266 |
| Issue | 5188 | Pages | 1208-12 |
| PubMed ID | 7973703 | Mgi Jnum | J:22696 |
| Mgi Id | MGI:70554 | Doi | 10.1126/science.7973703 |
| Citation | Saint-Ruf C, et al. (1994) Analysis and expression of a cloned pre-T cell receptor gene. Science 266(5188):1208-12 |
| abstractText | The T cell antigen receptor (TCR) beta chain regulates early T cell development in the absence of the TCR alpha chain. The developmentally controlled gene described here encodes the pre-TCR alpha (pT alpha) chain, which covalently associates with TCR beta and with the CD3 proteins forms a pre-TCR complex that transduces signals in immature thymocytes. Unlike the lambda 5 pre-B cell receptor protein, the pT alpha chain is a type I transmembrane protein whose cytoplasmic tail contains two potential phosphorylation sites and a Src homology 3 (SH3)-domain binding sequence. Pre-TCR alpha transfection experiments indicated that surface expression of the pre-TCR is controlled by additional developmentally regulated proteins. Identification of the pT alpha gene represents an essential step in the structure-function analysis of the pre-TCR complex. |
