| First Author | Xu H | Year | 1996 |
| Journal | J Immunol | Volume | 156 |
| Issue | 12 | Pages | 4909-14 |
| PubMed ID | 8648141 | Mgi Jnum | J:34009 |
| Mgi Id | MGI:81487 | Doi | 10.4049/jimmunol.156.12.4909 |
| Citation | Xu H, et al. (1996) Characterization of murine intercellular adhesion molecule-2. J Immunol 156(12):4909-14 |
| abstractText | Rat mAbs were raised against murine intercellular adhesion molecule-2 (ICAM-2). Immune precipitation and purification reveal that the murine ICAM-2 glycoprotein is 55 kDa and is similar in size to human ICAM-2. ICAM-2 is expressed on a variety of leukocyte cell lines, including T and B lymphoma, mastocytoma, and macrophage lines. ICAM-2 is well expressed on endothelioma cell lines, and in contrast to ICAM-1, expression is not increased by inflammatory cytokines. One of the mAb to ICAM-2 partially or completely inhibits binding of cells expressing LFA-1 to purified ICAM-2, and binding of cells expressing ICAM-2 to purified LFA-1. The findings in the mouse are congruent with those in the human, suggesting functional conservation of ICAM-2 across species. |
