Primary Identifier | MGI:5287375 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Ppp2r1a |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 3 was related with a modified exon 3 in which nucleotide substitution (GAG to GAC) results in the amino acid substitution of aspartic acid for glutamic acid at position 64 (E64D), mimicking a mutation found in a human lung carcinoma. A floxed neo cassette inserted downstream of the modified exon 3 was removed by cre-mediated recombination. |