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Allele : Tg(ACTB-SOD2)66Ysh transgene insertion 66, Ye-Shih Ho
Primary Identifier  MGI:3783732 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(ACTB-SOD2)66Ysh
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  cDNA for human mitochondrial superoxide dismutase (MnSOD or SOD2) was placed downstream of a human beta actin promoter and a 5' flanking sequence. The construct contained intron 1 sequence of the human beta actin gene to allow RNA splicing to occur. Line 66 was established. RNA blot analysis showed a 1.4 kb human MnSOD mRNA expressed in the mouse heart. Enzymatic activity in the heart is increased 325% relative to wild-type.
  • mutations:
  • Insertion
  • synonyms:
  • MnSOD-Tg,
  • MnSOD-Tg,
  • Tg(HMS)66,
  • TgHMS66,
  • TgHMS66,
  • Tg(HMS)66
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

17 Publication categories

Trail: Allele




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