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Allele : Cigs2<tm1.1Anse> conserved intergenic sequence 2; targeted mutation 1.1, K Mark Ansel
Primary Identifier  MGI:5313809 Allele Type  Targeted
Attribute String  Modified regulatory region, Null/knockout Gene  Cigs2
Transmission  Germline Strain of Origin  B6.Cg-Thy1<a>
Is Recombinase  false Is Wild Type  false
molecularNote  A loxP site flanked neomycin resistance gene cassette replaced the 810 bp encompassing the DNaseI hypersensitivity site 5 (HS5) in conserved non-coding sequence 2 (CNS-2) downstream of Il4, between it and Kif3a. Cre-mediated recombination removed the neo cassette. RT-PCR confirmed the reduction of Il4 and Il13 transcript expression in Th2 polarized CD4+ T cells.
  • mutations:
  • Intergenic deletion,
  • Insertion
  • synonyms:
  • HS V<->,
  • deltaV,
  • deltaV,
  • HS V<->
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

4 Publication categories

Trail: Allele




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