| Primary Identifier | MGI:97595 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 18750 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables calcium,diacylglycerol-dependent serine/threonine kinase activity; integrin binding activity; and lipid binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of bone resorption; and positive regulation of dense core granule biogenesis. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including cone photoreceptor outer segment; intercalated disc; and ooplasm. Part of alphav-beta3 integrin-PKCalpha complex. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). PHENOTYPE: Homozygous null mice show no overt macroscopic abnormalities, however examination of one line revealed increased cardiac muscle contractility and protection against heart failure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
