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Protein Coding Gene : Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Primary Identifier  MGI:1926943 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  192113
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable P-type potassium:proton transporter activity and P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within potassium ion homeostasis and regulation of pH. Located in basolateral plasma membrane. Is expressed in several structures, including gut; metanephros; pituitary gland; reproductive system; and thymus. Orthologous to human ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit).
PHENOTYPE: Homozygous mutation of this gene results in increased potassium excretion. When placed on a potassium-free diet, mutant animals display greater weight loss and slightly increased kidney weight compared to wild-type. [provided by MGI curators]
  • synonyms:
  • Atp1al1,
  • ATPase, H+/K+ transporting, nongastric, alpha polypeptide,
  • cHKA,
  • ATPase H+K+-transporting, alpha 2,
  • HKalpha2,
  • Atp12a

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For