| First Author | Sosinowski T | Year | 2001 |
| Journal | Immunity | Volume | 15 |
| Issue | 3 | Pages | 457-66 |
| PubMed ID | 11567635 | Mgi Jnum | J:71804 |
| Mgi Id | MGI:2150821 | Doi | 10.1016/s1074-7613(01)00195-9 |
| Citation | Sosinowski T, et al. (2001) The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity 15(3):457-66 |
| abstractText | In this report, we show that the Src-like adaptor protein (SLAP) plays an important role in thymocyte development. SLAP expression is developmentally regulated; it is low in CD4-CD8- thymocytes, it peaks in the CD4+CD8+ subset, and it decreases to low levels in more mature cells. Disruption of the SLAP gene leads to a marked upregulation of TCR and CD5 expression at the CD4+CD8+ stage. The absence of SLAP was also developmentally significant because it enhanced positive selection in mice expressing the DO11.10 transgenic T cell receptor. Moreover, SLAP deletion at least partially rescued the development of ZAP-70-deficient thymocytes. These results demonstrate that SLAP participates in a novel mechanism of TCR downregulation at the CD4+CD8+ stage and regulates positive selection. |
