| First Author | Takasaki M | Year | 2003 |
| Journal | Cancer Lett | Volume | 198 |
| Issue | 1 | Pages | 37-42 |
| PubMed ID | 12893428 | Mgi Jnum | J:84995 |
| Mgi Id | MGI:2671148 | Doi | 10.1016/s0304-3835(03)00285-4 |
| Citation | Takasaki M, et al. (2003) Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori. Cancer Lett 198(1):37-42 |
| abstractText | To search for cancer chemopreventive agents from natural resources, many phytochemicals and food additives have been screened. Consequently, two natural sweeteners, mogroside V and 11-oxo-mogroside V isolated from the fruits of Momordica grosvenori, exhibited strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). These sweet glycosides, having cucurbitane triterpenoid aglycon, exhibited the significant inhibitory effects on the two-stage carcinogenesis test of mouse skin tumors induced by peroxynitrite (ONOO(-)) as an initiator and TPA as a promoter. Further, 11-oxo-mogroside V also exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. |
