| First Author | Nakai Y | Year | 1998 |
| Journal | FEBS Lett | Volume | 433 |
| Issue | 1-2 | Pages | 143-8 |
| PubMed ID | 9738949 | Mgi Jnum | J:49555 |
| Mgi Id | MGI:1277693 | Doi | 10.1016/s0014-5793(98)00897-7 |
| Citation | Nakai Y, et al. (1998) cDNA cloning and characterization of mouse nifS-like protein, m-Nfs1: mitochondrial localization of eukaryotic NifS-like proteins. FEBS Lett 433(1-2):143-8 |
| abstractText | We have isolated a mouse cDNA which shows significant sequence similarity to the yeast nifS-like gene (y-NFS1), and termed it m-Nfs1. The deduced protein sequence (459 amino acids long) has several characteristic features common to those of bacterial NifS proteins, but distinct from them by its amino-terminal extension which contains a typical mitochondrial targeting presequence. m-Nfs1 was found to be a soluble 47-kDa protein in the matrix fraction of mouse liver mitochondria. The m-Nfs1 gene was ubiquitously expressed in most tissues, suggesting its housekeeping function in vivo. We also found that the gamma-NFS1 protein was localized in the mitochondrial matrix in yeast cells. These results suggest that both eukaryotic NifS-like proteins may play some roles in mitochondrial functions. |
